Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strong ultrafast nonlinear optical response from megaelectronvolt electrons in semiconductors.

Nature photonics·2026

Same author

Analog filtering methods improve leading edge timing performance of multiplexed SiPMs.

Physics in medicine and biology·2016

Same author

Achieving fast timing performance with multiplexed SiPMs.

Physics in medicine and biology·2016

Same author

Analog electro-optical readout of SiPMs achieves fast timing required for time-of-flight PET/MR.

Physics in medicine and biology·2015

Same author

Study of electrode pattern design for a CZT-based PET detector.

Physics in medicine and biology·2014

Same author

Readout strategy of an electro-optical coupled PET detector for time-of-flight PET/MRI.

Physics in medicine and biology·2013

Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026

Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026

Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026

Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026

Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026

Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 13, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

A multiplexed TOF and DOI capable PET detector using a binary position sensitive network.

M F Bieniosek¹, J W Cates, C S Levin

¹Department of Radiology, Stanford University, Stanford, CA 94305, USA. Molecular Imaging Program at Stanford (MIPS), Stanford, CA 94305, USA. Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.

Physics in Medicine and Biology

|October 15, 2016

Summary

This summary is machine-generated.

This study presents a low-complexity, room-temperature Positron Emission Tomography (PET) module with Time of Flight (TOF) and Depth of Interaction (DOI) capabilities, improving image quality. The novel design simplifies construction for high-performance PET detectors.

More Related Videos

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Related Experiment Videos

Last Updated: Mar 13, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Area of Science:

Medical Imaging
Nuclear Physics
Instrumentation

Background:

Positron Emission Tomography (PET) imaging quality is enhanced by Time of Flight (TOF) and Depth of Interaction (DOI) capabilities.
Existing TOF/DOI PET detectors often involve complex readout systems, increasing cost and engineering challenges.

Purpose of the Study:

To develop a high-performance, low-complexity, room-temperature TOF/DOI PET module.
To reduce the electronic readout complexity of PET detectors while maintaining excellent performance.

Main Methods:

Utilized multiplexed timing channels to decrease electronic readout complexity.
Employed a two-layer, light-sharing scintillation crystal array for DOI determination.
Implemented a novel binary position-sensitive network with silicon photomultipliers (SiPMs).

Main Results:

Achieved a coincidence time resolution of 180 ± 2 ps with 10 mm DOI resolution and 11% energy resolution using four SiPMs.
Obtained a coincidence time resolution of 204 ± 1 ps with 10 mm DOI resolution and 15% energy resolution using sixteen SiPMs.
Demonstrated excellent timing, energy, and position resolution at room temperature.

Conclusions:

The presented methods significantly simplify the construction of high-performance TOF/DOI PET detectors.
This approach offers a viable path towards more accessible and advanced PET imaging technology.