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Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities

Sebastien Boucle1, Leda Bassit1, Maryam Ehteshami1

  • 1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Center for AIDS Research, Emory University School of Medicine, 1760 Haygood Drive, Atlanta, GA 30322, USA.

Clinics in Liver Disease
|October 16, 2016
PubMed

Hepatitis B virus (HBV) causes significant morbidity and mortality worldwide. The majority of chronically infected individuals do not achieve a functional and complete cure. Treated persons who achieve a long-term sustained virologic response (undetectable HBV DNA), are still at high risk of developing morbidity and mortality from liver complications. This review focuses on novel, mechanistically diverse anti-HBV therapeutic strategies currently in development or in clinical evaluation, and highlights new combination strategies that may contribute to full elimination of HBV DNA and covalently closed circular DNA from the infected liver, leading to a complete cure of chronic hepatitis B.

Keywords:
Anti-HBV agentsAntiviral therapyCRISPR/Cas9HBV cureHBsAgcccDNAsiRNA

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