Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

Structure of Cardiac Muscles

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction.

Cardiovascular research·2026

Same author

PDGFRα+ fibroblast ablation exacerbates pathologic features in a model of house dust mite-induced allergenic asthma.

Disease models & mechanisms·2025

Same author

Reformulation of the Necroptosis Pathway in Reperfused Myocardial Infarction.

Circulation·2025

Same author

Analysis of cellular NO-GC expression in the murine heart and lineage determination in angiotensin II-induced fibrosis.

iScience·2025

Same author

SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone.

PLoS pathogens·2025

Same author

RGD peptide promotes follicle growth through integrins αvβ3/αvβ5 in three-dimensional culture.

Reproduction (Cambridge, England)·2024

Same journal

Non-Culprit Lesion Plaque Vulnerability Progression and Regression Assessed by Serial Optical Coherence Tomography Imaging.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same journal

Reduction in Heart Failure Hospitalizations Through Real-World HeartLogic<sup>TM</sup> Alert Response　- A Multicenter Study in Japan.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same journal

JCS/JPCPHS 2025 Guideline on Pulmonary Hypertension and Pulmonary Embolism/Deep Vein Thrombosis.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same journal

Cardiac Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia　- Target Definition, Dose Distribution, and Clinical Trajectory.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same journal

Myocardial Perfusion and Fluorodeoxyglucose Uptake Patterns in Cardiac Sarcoidosis Stratified by Diagnostic Category and Systemic Involvement.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same journal

A High Level of Calculated Small Dense Low-Density Lipoprotein Cholesterol Is an Independent Risk Factor for the Progression of Renal Impairment.

Circulation journal : official journal of the Japanese Circulation Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 13, 2026

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

Defining the Cardiac Fibroblast.

Malina J Ivey¹, Michelle D Tallquist

¹Department of Cell and Molecular Biology, Center for Cardiovascular Research, University of Hawaii.

Circulation Journal : Official Journal of the Japanese Circulation Society

|October 18, 2016

Summary

This summary is machine-generated.

Recent advances in fibroblast identification enable a better understanding of cardiac fibrosis. Resident cardiac fibroblasts are key contributors to heart remodeling after injury, offering new therapeutic targets.

More Related Videos

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

Related Experiment Videos

Last Updated: Mar 13, 2026

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

Area of Science:

Cardiovascular Biology
Cell Biology
Fibrosis Research

Background:

Cardiac fibrosis is a significant health issue.
Studying fibroblast biology has been challenging due to identification and tracking limitations.
Recent progress in lineage tracing and reporter systems has improved fibroblast research.

Purpose of the Study:

To review recent findings on the origin and identity of cardiac fibroblasts.
To discuss the role of fibroblasts in cardiac remodeling and fibrosis.
To highlight the developing understanding of fibroblast biology in cardiovascular health.

Main Methods:

Review of recent scientific literature.
Analysis of studies employing fibroblast-specific lineage tags and reporters.
Synthesis of emerging research on cell types contributing to extracellular matrix production.

Main Results:

Multiple cell types can produce extracellular matrix after cardiac injury.
Emerging evidence points to resident cardiac fibroblasts as major contributors to remodeling.
Advances in technology are improving the ability to understand fibroblast gene expression and behavior.

Conclusions:

Understanding cardiac fibroblast origin and identity is crucial for addressing fibrosis.
Fibroblast biology research is rapidly evolving, promising future insights.
New findings lay the groundwork for understanding fibroblast roles in cardiac injury and repair.