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Related Experiment Videos

Dentin permeability: changes produced by iontophoresis.

D H Pashley, M J Livingston, W C Outhwaite

    Journal of Dental Research
    |January 1, 1978
    PubMed
    Summary

    Iontophoresis significantly enhances the penetration of ionized substances through dentin. This method shows promise for improving the delivery of therapeutic agents via the dentin layer.

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    Area of Science:

    • Biomaterials Science
    • Dental Research
    • Pharmacokinetics

    Background:

    • Dentin, a biological tissue, presents a barrier to the effective delivery of therapeutic agents.
    • Ionized substances require enhanced methods for efficient permeation through biological tissues like dentin.
    • Current drug delivery methods face challenges in achieving adequate concentrations within dentin.

    Purpose of the Study:

    • To investigate the efficacy of iontophoresis in enhancing the permeation of ionized substances across human dentin.
    • To determine the effect of electrode polarity on the permeation rates of different ionized molecules.
    • To assess the potential of iontophoresis as a novel drug delivery strategy for dental applications.

    Main Methods:

    • Human third molar dentin disks were prepared for experimental analysis.
    • Iontophoretic currents ranging from 0 to 1.0 mA were applied to the dentin samples.
    • The permeation of radio-labeled iodide (125I) and lidocaine (14C-lidocaine) was quantified under different electrical conditions.

    Main Results:

    • Application of a negative electrode significantly increased 125I-permeation by a factor of 10.
    • Application of a positive electrode enhanced 14C-lidocaine permeation by a factor of 8.
    • Both electrode polarities demonstrated a substantial increase in the permeation of respective ionized substances.

    Conclusions:

    • Iontophoresis is a viable method for increasing the permeation of ionized substances through dentin.
    • The polarity of the iontophoretic current can be optimized to enhance the delivery of specific ionized therapeutic agents.
    • This technique holds significant promise for improving drug delivery in dentistry, potentially leading to more effective treatments.

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