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Engineered bifunctional proteins and stem cells: next generation of targeted cancer therapeutics

Sung Hugh Choi1, Khalid Shah2,3

  • 1Stem Cell Therapeutics and Imaging Program, Molecular Neurotherapy and Imaging Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

Discovery Medicine
|October 19, 2016
PubMed

Insights

Targeting multiple cancer signaling pathways simultaneously with novel therapeutics, including engineered stem cells, is crucial for overcoming treatment resistance and improving targeted cancer therapy efficacy.

Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Molecular Biology

Background:

  • Redundant tumor survival signaling pathways and their crosstalk impede effective targeted cancer therapies.
  • Developing multi-targeting agents and efficient delivery platforms is critical for future cancer treatments.

Purpose of the Study:

  • To review the design and efficacy of therapeutics targeting multiple cancer pathways.
  • To explore the potential of engineered therapeutic stem cells for delivering bifunctional agents.

Main Methods:

  • Review of bifunctional multi-targeting antibodies, fusion proteins, and oncolytic viruses.
  • Discussion of stem cell engineering for targeted drug delivery.

Main Results:

  • Bifunctional agents and engineered stem cells show promise in targeting multiple cancer pathways.
  • These approaches address key challenges in current targeted cancer therapy.

Conclusions:

  • Targeting multiple pathways and utilizing advanced delivery systems like engineered stem cells are vital for advancing targeted cancer therapies.
  • Further research into these combined strategies holds significant therapeutic potential.

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