Related Experiment Video
Updated: Mar 13, 2026
06:32
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
7.1K
CHOROIDAL SARCOID GRANULOMA SIMULATING PROSTATE CARCINOMA METASTASIS
Elif B Turkoglu1, Sara E Lally, Carol L Shields
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retinal Cases & Brief Reports
|October 21, 2016
Summary
A rare choroidal sarcoid granuloma mimicked prostate cancer metastasis in a patient. Prompt treatment with prednisone led to tumor resolution, aiding diagnosis.
Area of Science:
- Ophthalmology
- Oncology
- Immunology
Background:
- Prostate carcinoma can rarely metastasize to the uvea.
- Sarcoidosis is a multisystem inflammatory disease that can affect the eye.
- Distinguishing choroidal metastasis from other choroidal masses is crucial for patient management.
Observation:
- A 66-year-old male with a history of pulmonary sarcoidosis and prostate carcinoma presented with an asymptomatic choroidal mass.
- Ocular examination revealed a 2 mm yellow choroidal mass without signs of inflammation or fluid.
- Optical coherence tomography showed a homogenous hyporeflective choroidal mass compressing vascular structures.
Findings:
- The choroidal mass in this patient with prostate carcinoma was diagnosed as sarcoid granuloma.
- Treatment with oral prednisone resulted in significant tumor resolution.
- Optical coherence tomography confirmed the reduction in mass size after 2 months of therapy.
Implications:
- Choroidal sarcoid granuloma should be considered in the differential diagnosis of choroidal masses, especially in patients with a history of sarcoidosis.
- The response to corticosteroid therapy can aid in differentiating sarcoid granuloma from metastasis.
- This case highlights the importance of a comprehensive diagnostic approach in managing ocular tumors.
