[Clinical and pathological analysis of ocular tumors in 504 children cases]

Objective: To analyze the clinical features and pathological classification of chlidren's ocular tumors. Methods: Retrospective case series study. Five hundred and four cases (506 eyes) of ocular tumor with biopsy-proven in children below 14 years old between January 2002 and December 2014 from Tianjin Eye Hospital were performed to retrospectively investigated the lesion location, clinical features and histopathologic classification of these lesions. Results: Of 504 cases there were 246 boys (248 eyes) and 258 girls (258 eyes) patients. The mean age at diagnosis was 6.4 years, ranged from 4 months to 14 years. Of 328 cases (65.1%) of eyelid and ocular surface, 2 cases (0.6%) were malignant tumors and other tumors were all benign tumors. The leading four tumors were corneal dermoid, dermoid cysts, nevus and pilomatricoma. Of 123 cases (24.4%) of orbital tumors, 13 cases (10.6%) were malignant tumors and other tumors were all benign tumors. The leading four tumors were dermoid cysts, lymphangiomas, hemolymphangioma and venous hemangioma. Of 53 cases (10.5%) of intraocular tumors, 41 cases (77.4%) were malignant tumors which were all retinoblastoma. Conclusions: Most of children's ocular tumors were congenital and embryonic tumors. The most common ocular tumors of 504 children patients were from eyelid and ocular surface. Corneal dermoid and dermoid cysts were the most benign ones. Retinoblastoma and rhabdomyosarcoma were the most malignant ones.(Chin J Ophthalmol, 2016, 52: 764-768).