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Antibiotic Resistance in Pediatric Urinary Tract Infections

Jeremy S Stultz1, Christopher D Doern2, Emily Godbout3

  • 1Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University School of Pharmacy, Smith Building, Room 435, 410 N 12th Street, P.O. Box 980533, Richmond, VA, 23298, USA. jsstultz@vcu.edu.

Current Infectious Disease Reports
|October 21, 2016
PubMed

Insights

Antibiotic resistance in pediatric urinary tract infections (UTIs) is rising, particularly with prior antibiotic exposure. Judicious prescribing is crucial to combat resistant organisms and improve treatment outcomes.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial resistance
  • Urology

Background:

  • Urinary tract infections (UTIs) are a significant concern in pediatric populations.
  • Increasing antibiotic resistance rates pose a challenge to effective UTI treatment.
  • Prior antibiotic exposure is a key risk factor for resistant UTI pathogens.

Approach:

  • Reviewing current trends in pediatric UTI antibiotic resistance.
  • Identifying risk factors associated with resistant organism acquisition.
  • Highlighting the need for judicious antibiotic prescribing in children.
  • Examining the challenges in treating complex pediatric UTIs.

Key Points:

  • Pediatric UTIs demonstrate increasing resistance to common antibiotics.
  • Previous antibiotic use elevates the risk of acquiring resistant bacteria.
  • Children with complex medical histories are susceptible to multidrug-resistant organisms like ESBL-producers.
  • There is a lack of data on how antibiotic susceptibility testing impacts UTI treatment success.

Conclusions:

  • Urgent need for antibiotic stewardship in pediatric care to mitigate resistance.
  • Further research is required to understand the clinical impact of antibiotic susceptibility testing in pediatric UTIs.
  • Addressing antibiotic resistance in pediatric UTIs is critical for public health.

Keywords:
Extended spectrum beta-lactamasesMicrobial sensitivity testsPediatricUrinary tract infections

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