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Fahr's Disease with Seizure Presentation
Rangaswamy1, V Ranjith2, L Vikas1
1Asst. Prof.
The Journal of the Association of Physicians of India
|October 21, 2016
Summary
Fahr's disease, a rare neurodegenerative condition, involves brain calcifications and diverse neurological and psychiatric symptoms. Diagnosis relies on clinical signs, imaging, and ruling out biochemical issues.
Area of Science:
- Neurology
- Neurodegenerative Diseases
- Radiology
Background:
- Fahr's disease (or syndrome) is a rare neurodegenerative disorder.
- It is characterized by symmetrical calcifications in specific brain regions.
Observation:
- Calcifications often affect the basal ganglia, thalami, white matter, and cerebellar nuclei.
- The condition can be idiopathic or linked to endocrinopathies, particularly parathyroid disorders.
Findings:
- Clinical presentation is highly variable, including seizures, syncope, stroke-like events, and extra-pyramidal symptoms.
- Behavioral and psychiatric issues like psychosis, mood disorders, and dementia are common.
Implications:
- Diagnosis requires a combination of clinical evaluation, assessment of neurological decline, and characteristic radiological findings.
- Distinguishing Fahr's disease involves excluding biochemical abnormalities.
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