Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.2K
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

2.2K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.2K
Understanding Sleep01:11

Understanding Sleep

1.8K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual Pattern of Cerebral Electrical Activity in the Mongolian Hamster (Allocricetulus curtatus) During Heterothermia.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2025
Same author

Identification of targetable epigenetic vulnerabilities for uveal melanoma.

bioRxiv : the preprint server for biology·2024
Same author

Early Postnatal Experience Modifies Activation of the Pituitary Testicular Complex in Male House Mice (Mus Musculus) Exposed to the Odor of Receptive Con- and Heterospecific Females.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2023
Same author

Motor Activity and "Neotenic" Sleep in the Naked Mole Rat (Heterocephalus glaber) under Isolation.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2021
Same author

[D-lactate as a novel somnogenic factor?]

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2020
Same author

[Sleep-wake cycle and experimental models of Panx1 mutations].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2019

Related Experiment Video

Updated: Mar 13, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.7K

Sleep-wakefulness cycle and behavior in pannexin1 knockout mice.

V M Kovalzon1, L S Moiseenko1, A V Ambaryan1

  • 1Severtsov Institute Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.

Behavioural Brain Research
|October 30, 2016
PubMed
Summary

Mice lacking Pannexin1 (Panx1) exhibit altered sleep-wake cycles, with increased waking and reduced slow-wave sleep, suggesting Panx1 influences sleep regulation via extracellular adenosine signaling.

Keywords:
ATPAdenosineGene knockout modelsHemichannelsPannexinPurinergic signalingSleep

More Related Videos

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.6K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

Related Experiment Videos

Last Updated: Mar 13, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.7K
Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.6K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Sleep Research

Background:

  • Pannexins are membrane channel proteins involved in critical biological processes.
  • Pannexin1 (Panx1) hemichannels facilitate ATP efflux, contributing to extracellular adenosine signaling.
  • Adenosine is a key paracrine factor in regulating slow-wave sleep.

Purpose of the Study:

  • To investigate the role of pannexin1 in sleep-wake cycle regulation.
  • To test the hypothesis that Panx1 influences sleep through extracellular adenosine.

Main Methods:

  • Comparison of EEG and movement activity in Panx1 knockout (Panx1-/-) and wild-type (Panx1+/+) mice.
  • Analysis of sleep rebound after sleep deprivation.
  • Behavioral tests assessing motor activity.

Main Results:

  • Panx1-/- mice showed increased waking and decreased slow-wave sleep, particularly during the dark period.
  • Movement activity was significantly higher in Panx1-/- mice.
  • Sleep rebound after deprivation was unchanged, but motor behaviors differed.

Conclusions:

  • Pannexin1 appears to contribute to sleep-wake cycle regulation, potentially by modulating extracellular adenosine levels.
  • The absence of Panx1 may lead to reduced extracellular adenosine, impacting sleep architecture.
  • Further research is needed to fully elucidate Panx1's role in sleep physiology and behavior.