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Heparinizable segmented polyurethanes containing poly-amidoamine blocks.

M C Tanzi1, M Levi

  • 1Dept. Chimica Industriale e Ingegneria Chimica G. Natta, Milano, Italy.

Journal of Biomedical Materials Research
|August 1, 1989
PubMed
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Researchers developed novel poly-ether-urea-urethane copolymers with varying poly-amidoamine content. These materials show potential for biomedical applications due to their evaluated blood compatibility and cytotoxicity.

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science

Background:

  • Poly-ether-urea-urethanes are versatile biomaterials.
  • Incorporating specific segments can tailor material properties for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize novel poly-ether-urea-urethane copolymers.
  • To evaluate the influence of poly-amidoamine segments on material properties and hemocompatibility.

Main Methods:

  • Copolymerization of 4,4'-diphenylmethanediisocyanate (MDI), propanediamine, and poly-oxytetra-methylene glycol.
  • Synthesis of amino-terminated poly-amidoamine macromonomers.
  • Physicochemical, mechanical, heparin adsorption, blood compatibility, and cytotoxicity testing.

Main Results:

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  • Three distinct copolymers were synthesized with varying poly-amidoamine content (0, 6, and 15 wt%).
  • Key physicochemical and mechanical properties were determined for each copolymer.
  • Heparin adsorption, blood compatibility, and cytotoxicity were evaluated.

    • Conclusions:

    • Novel poly-ether-urea-urethane copolymers with tunable properties were successfully synthesized.
    • The incorporation of poly-amidoamine segments influences the material's performance in biological assessments.
    • These materials warrant further investigation for potential biomedical applications.