Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

6.5K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.5K
Cells of the Epidermis01:24

Cells of the Epidermis

8.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
8.6K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.2K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

sQUIZ your knowledge! A hidden flexural pattern revealed.

European journal of dermatology : EJD·2026
Same author

Patient Satisfaction Using Guselkumab Self-administered Using the One-Press Device for Treatment of Moderate-to-Severe Psoriasis: Results from a National, Prospective, Real-World Study in Portugal (CERES Study).

Dermatology and therapy·2026
Same author

Real-World Effectiveness, Safety and Drug Survival of Tildrakizumab in Adult Patients With Plaque Psoriasis: A 2-Year Portuguese Multicenter Retrospective Cohort Study.

International journal of dermatology·2025
Same author

Cutaneous non-volar melanoma dermoscopy and histopathology correlation: a systematic review protocol.

BMJ open·2025
Same author

Update on Generalized Pustular Psoriasis.

Acta medica portuguesa·2025
Same author

Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD.

Dermatology and therapy·2025

Related Experiment Video

Updated: Mar 13, 2026

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
08:09

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

Published on: August 4, 2016

12.3K

Multiple Minute Digitate Hyperkeratosis in an Infant.

Felicidade Santiago1, Katarina Kieselova1, Gustavo Januário2

  • 1Department of Dermatology, Centro Hospitalar de Leiria, Leiria, Portugal.

Pediatric Dermatology
|October 26, 2016
PubMed
Summary

A rare form of multiple minute digitate hyperkeratoses was observed in an infant. This transient skin condition was exclusively located in the anogenital region.

More Related Videos

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.2K
Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
08:36

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Published on: August 20, 2015

12.1K

Related Experiment Videos

Last Updated: Mar 13, 2026

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
08:09

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

Published on: August 4, 2016

12.3K
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.2K
Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
08:36

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Published on: August 20, 2015

12.1K

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Clinical Case Reports

Background:

  • Multiple minute digitate hyperkeratoses (MMDH) is a rare genodermatosis.
  • Typically presents in adulthood with characteristic palmoplantar and dorsal knuckle hyperkeratosis.

Observation:

  • A unique case of MMDH is presented in a healthy 4-month-old boy.
  • The hyperkeratoses were exclusively located in the anogenital area.
  • The condition exhibited a transitory nature, resolving spontaneously.

Findings:

  • This report describes a distinct variant of MMDH.
  • The presentation differs significantly from typical MMDH regarding age of onset, location, and duration.
  • Anogenital MMDH in infancy represents a novel clinical manifestation.

Implications:

  • Highlights the potential for atypical presentations of MMDH in infants.
  • Suggests the need for broader differential diagnoses in pediatric anogenital dermatoses.
  • Contributes to the understanding of the phenotypic variability of MMDH.