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Assortative Mating and Linkage Disequilibrium.
1School of Life Sciences, Arizona State University, Tempe, Arizona 85287 philip.hedrick@asu.edu.
G3 (Bethesda, Md.)
|October 28, 2016
Summary
Assortative mating
Area of Science:
- Population genetics
- Quantitative genetics
Background:
- Assortative mating may increase heritability and additive genetic variance.
- This increase is hypothesized to occur via enhanced linkage disequilibrium.
Purpose of the Study:
- To explicitly examine the impact of assortative mating on linkage disequilibrium.
- To compare findings across different assortative mating models.
Main Methods:
- Analysis of Wright's (1921) two-locus model.
- Examination of two selective assortative mating models.
Main Results:
- High assortative mating in Wright's model generated positive linkage disequilibrium, independent of recombination.
- Selective models produced negative linkage disequilibrium, dependent on recombination.
- Low levels of assortative mating yielded minimal linkage disequilibrium.
Conclusions:
- The effect of assortative mating on linkage disequilibrium is model-specific.
- Consequent impacts on heritability and additive genetic variance appear minor and dependent on the model used.
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