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Treatment of systemic-onset juvenile arthritis with canakinumab

Joachim Peitz1, Gerd Horneff1

  • 1Pediatric Rheumatology Centre, Department of General Pediatrics and Neonatology, Asklepios Clinic, Sankt Augustin, Germany.

Open Access Rheumatology : Research and Reviews
|February 18, 2015
PubMed

Treatment of systemic-onset juvenile idiopathic arthritis is challenging, but the availability of cytokine antagonists targeting interleukin-1 and interleukin-6 have markedly advanced the therapeutic options. In this review, we focus on the current experience with canakinumab, an interleukin-1 monoclonal human antibody for the treatment of systemic-onset juvenile idiopathic arthritis and describe its efficacy and safety. Canakinumab is an important, safe, and valid drug in the treatment of systemic-onset juvenile idiopathic arthritis.

Keywords:
anakinracanakinumabinterleukin-1interleukin-6systemic-onset juvenile idiopathic arthritis

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