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Updated: Jul 21, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Process Chemistry in Antiviral Research
Yong-Li Zhong1, Nobuyoshi Yasuda2, Hongming Li2
1Department of Process Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ, 07065, USA. yongli_zhong@merck.com.
Abstract:
This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process chemistry that enabled access to these important drugs. In particular, process chemistry highlights from the practical syntheses of the HCV drugs sofosbuvir (Gilead), grazoprevir (Merck), and elbasvir (Merck), the HIV therapy darunavir (Tibotec) and the influenza treatment peramivir (BioCryst) are presented.
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