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The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance.

N Kikuchi1, N Fuku2, R Matsumoto3

  • 1Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan.

International Journal of Sports Medicine
|November 5, 2016
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The MCT1 T1470A polymorphism

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Area of Science:

  • Sports Science
  • Genetics
  • Human Physiology

Background:

  • The MCT1 gene plays a role in lactate transport.
  • Genetic variations in MCT1 may influence athletic performance.
  • Understanding these variations can aid in athlete selection and training.

Purpose of the Study:

  • To examine the association between the MCT1 T1470A polymorphism (rs1049434) and athletic performance in Japanese wrestlers.
  • To investigate the impact of this polymorphism on blood lactate concentrations during and after anaerobic exercise.

Main Methods:

  • Genotyping of 199 Japanese wrestlers and 649 controls for the MCT1 T1470A polymorphism using TaqMan® Assay.
  • Performance testing in 46 wrestlers using the 30-s Wingate Anaerobic test (WAnT) and repeated 10-s sprints.
  • Measurement of blood lactate levels pre-exercise, during exercise, and post-exercise.

Main Results:

  • The AA genotype of the MCT1 T1470A polymorphism was significantly more frequent in wrestlers than controls.
  • Wrestlers with the AA genotype exhibited lower blood lactate levels post-WAnT and after repeated sprints compared to other genotypes.
  • This suggests a potential genetic predisposition for power-oriented performance and altered lactate metabolism in wrestlers.

Conclusions:

  • The AA genotype of the MCT1 T1470A polymorphism is over-represented in Japanese wrestlers.
  • This genotype is associated with reduced blood lactate accumulation during intense anaerobic exercise.
  • The findings indicate a potential role for the MCT1 T1470A polymorphism in elite wrestling performance.