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Metabolic support for the heart: complementary therapy for heart failure?
Ward A Heggermont1,2,3, Anna-Pia Papageorgiou1,2, Stephane Heymans1,2
1Centre for Molecular and Vascular Biology, Department of Cardiovascular Research, University of Leuven, Belgium.
European Journal of Heart Failure
|November 5, 2016
Summary
Heart failure increases energy needs while reducing efficiency. Therapies targeting cardiac metabolism could improve treatments for heart failure patients, complementing existing hemodynamic therapies.
Area of Science:
- Cardiology
- Metabolic Medicine
- Biochemistry
Background:
- Heart failure presents a dual challenge: elevated metabolic demand coupled with reduced energy efficiency.
- Metabolic dysfunction is well-documented in heart failure with reduced ejection fraction and increasingly recognized in heart failure with preserved ejection fraction.
Purpose of the Study:
- To review the fundamental aspects of normal cardiac metabolism.
- To outline the characteristic metabolic alterations observed in heart failure.
- To discuss established and emerging therapeutic strategies focused on modulating cardiac metabolism.
Main Methods:
- Literature review of cardiac metabolism in health and disease.
- Analysis of metabolic disturbances in various heart failure phenotypes.
- Examination of therapeutic targets influencing cardiac energy metabolism.
Main Results:
- Normal cardiac metabolism relies on efficient substrate utilization.
- Heart failure is characterized by significant metabolic reprogramming, impacting energy production.
- Current treatments primarily address hemodynamics, not the heart's energetic deficit.
Conclusions:
- Targeting cardiomyocyte metabolism offers a promising complementary approach to current heart failure therapies.
- Understanding and intervening in cardiac metabolic pathways are crucial for improving heart failure management.
- Further research into metabolic interventions is warranted for both reduced and preserved ejection fraction heart failure.
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