Related Experiment Video
Updated: Mar 12, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Published on: July 12, 2021
Parental weighting of seizure risks vs. fever risks in vaccination tradeoff decisions
Brian J Zikmund-Fisher1, Eve Wittenberg2, Tracy A Lieu3
1Department of Health Behavior and Health Education, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States; Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann Arbor, MI, United States.
Abstract:
As part of a survey of about vaccination beliefs, a nationally representative sample of parents of young children answered a series of tradeoff questions that asked them to choose between two vaccination approaches that differed in terms of risks of vaccine complications, number of injections, and/or vaccine effectiveness. Most parents were willing to have their children endure more injections, and many were willing to forgo disease protection, in order to reduce the rare chance of febrile seizures. Yet, most parents were unwilling to trade disease protection to reduce the risk of fever alone, even though this is correlated with the risk of febrile seizures. Vaccine risk communications need to address the heightened emotional weight that parents give to febrile seizure risk, even when the rarity of such events is explicit.
Related Concept Videos
Vaccinations
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Drug Dosing: Infants and Children
Bias in Epidemiological Studies
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Relative Risk

