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Updated: Mar 12, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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[Cutaneous manifestations in renal diseases]
M Schmid-Simbeck1,2, A Udvardi3,4, B Volc-Platzer3,4
1Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich. martina.schmid-simbeck@wienkav.at.
Summary
Skin conditions like pallor and dryness are common in renal failure, alongside severe diseases such as calciphylaxis and nephrogenic systemic fibrosis. Early recognition of these skin symptoms aids in diagnosing kidney disease.
Area of Science:
- Dermatology
- Nephrology
- Internal Medicine
Background:
- Renal failure presents with diverse skin manifestations, ranging from general changes (pallor, dryness) to specific, severe conditions.
- Nephrogenic pruritus is a frequent and debilitating symptom in patients with kidney disease.
- Several specific dermatological conditions are associated with renal failure, including acquired perforating dermatoses, calciphylaxis, and bullous lesions due to porphyrin metabolism disturbances.
Purpose of the Study:
- To provide a comprehensive overview of skin manifestations associated with renal failure.
- To highlight the correlations between specific skin symptoms and kidney diseases.
- To emphasize the importance of early diagnosis and management of these conditions.
Main Methods:
- Literature review of skin conditions in renal failure patients.
- Discussion of systemic diseases with concurrent skin and kidney involvement.
- Overview of genodermatoses with cutaneous and renal manifestations.
Main Results:
- Patients with renal failure may develop specific diseases like calciphylaxis (poor prognosis, sepsis risk) and nephrogenic systemic fibrosis (incidence declining).
- Systemic diseases such as connective tissue diseases, vasculitis, sarcoidosis, and amyloidosis exhibit both skin and kidney symptoms.
- Post-kidney transplantation, vigilance for skin tumors and infections is crucial.
Conclusions:
- Understanding the link between characteristic skin symptoms and kidney disease is vital for timely investigation and referral to nephrologists.
- Early identification of dermatological signs can facilitate prompt diagnosis and management of underlying renal pathology.
- This review underscores the interdisciplinary approach required for managing patients with combined skin and kidney conditions.
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