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Related Experiment Video

Updated: Mar 12, 2026

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction

Published on: May 7, 2015

Hyperbaric oxygen modalities are differentially effective in distinct brain ischemia models.

Robert P Ostrowski¹, Katarzyna Stępień¹, Emanuela Pucko¹

¹Department of Experimental and Clinical Neuropathology, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

Medical Gas Research

|November 10, 2016

Summary

Hyperbaric oxygen (HBO) shows promise in treating ischemic brain injuries, but timing is crucial. Early HBO treatment offers protection, while delayed treatment may worsen outcomes.

Keywords:

animal models brain injury cell death cerebral ischemia hippocampus hyperbaric oxygen infarction volume preconditioning therapeutic window

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Last Updated: Mar 12, 2026

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Area of Science:

Neuroscience
Hyperbaric Medicine
Cerebrovascular Diseases

Background:

Experimental models show hyperbaric oxygen (HBO) effectiveness for ischemic cerebrovascular diseases.
HBO demonstrates efficacy in global brain ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia encephalopathy.

Approach:

This review analyzes the impact of HBO timing on brain injury.
It evaluates HBO preconditioning and post-treatment strategies.
The review considers combined preconditioning and post-treatment for synergistic effects.

Key Points:

Early and repetitive HBO post-treatment enhances protection against brain ischemia.
Delayed HBO treatment after transient focal ischemia may exacerbate brain injury.
Injury reduction levels are key for translational evaluation of HBO therapies.

Conclusions:

HBO timing significantly influences its therapeutic effect in ischemic brain injury.
Further research into combined HBO preconditioning and post-treatment is warranted.
HBO holds potential for treating various ischemic cerebrovascular conditions.