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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
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Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice
Lander Foquet1, Elizabeth M Wilson2, Lieven Verhoye1
1Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.
Methods in Molecular Biology (Clifton, N.J.)
|November 11, 2016
Abstract:
Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.
