Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...

G Protein-coupled Receptors

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

Transducer Mechanism: G Protein–Coupled Receptors

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Administration of human macrophage colony-stimulating factor-mFc fusion protein increases macrophage phagocytic capacity and stimulates liver regeneration in mice.

Journal of inflammation (London, England)·2026

Same author

Loss of proton-sensing TDAG8 increases tumor progression in mouse models of colon cancer.

Molecular oncology·2026

Same author

An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling.

bioRxiv : the preprint server for biology·2026

Same author

Adhesion G protein-coupled receptors.

Pharmacological reviews·2026

Same author

Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition.

Nature communications·2026

Same author

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung.

Frontiers in immunology·2026

Same journal

Endothelial Cell Phenotypic Plasticity in Atherosclerosis.

Handbook of experimental pharmacology·2026

Same journal

Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder.

Handbook of experimental pharmacology·2026

Same journal

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026

Same journal

Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes.

Handbook of experimental pharmacology·2026

Same journal

Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron.

Handbook of experimental pharmacology·2026

Same journal

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Handbook of experimental pharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Adhesion GPCR Function in Pulmonary Development and Disease.

Marie-Gabrielle Ludwig¹, Klaus Seuwen¹, James P Bridges^2,3

¹Novartis Institutes for Biomedical Research, Basel, 4056, Switzerland.

Handbook of Experimental Pharmacology

|November 11, 2016

Summary

This summary is machine-generated.

Adhesion GPCRs (aGPCRs) are increasingly recognized for their roles in lung development and disease. This review focuses on available data for aGPCRs in pulmonary biology, highlighting Adgrf5.

Keywords:

Alveolar epithelium COPD Lung development Lung disease Lung homeostasis Pulmonary surfactant

More Related Videos

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

Studying Wnt Signaling During Patterning of Conducting Airways

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Related Experiment Videos

Last Updated: Mar 12, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

Studying Wnt Signaling During Patterning of Conducting Airways

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Area of Science:

Pulmonary Biology
Cellular Signaling
Molecular Medicine

Background:

G-protein-coupled receptors (GPCRs) are crucial in pulmonary physiology and disease treatment.
Adhesion GPCRs (aGPCRs) are an emerging class with significant, yet understudied, roles in lung biology.
Current understanding of aGPCRs in pulmonary contexts is limited but growing.

Purpose of the Study:

To review existing literature on adhesion GPCRs (aGPCRs) in pulmonary biology.
To highlight the known functions and implications of aGPCRs in lung development, homeostasis, and disease.
To focus on Adgrf5, the aGPCR with the most available data in this field.

Main Methods:

Literature review of studies involving aGPCRs and pulmonary systems.
Analysis of data from loss-of-function experiments and pharmacologic studies.
Synthesis of current knowledge regarding specific aGPCRs, particularly Adgrf5.

Main Results:

Classic GPCRs extensively influence lung function and are therapeutic targets.
Adhesion GPCRs (aGPCRs) play critical roles in lung development, maintenance, and pathology.
Adgrf5 is the most studied aGPCR in the pulmonary system to date, with substantial data emerging.

Conclusions:

Adhesion GPCRs (aGPCRs) represent a promising area for understanding and treating pulmonary diseases.
Further research into aGPCRs, especially Adgrf5, is warranted to elucidate their full therapeutic potential.
This review consolidates current knowledge, serving as a foundation for future investigations into aGPCRs in lung biology.