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Updated: Mar 12, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Current practice of hypoglycemia management in the ED
Matthew H Bilhimer1, Cierra N Treu1, Nicole M Acquisto2
1Department of Pharmacy, University of Rochester Medical Center, Rochester, NY.
A significant portion of emergency department patients experienced refractory or recurrent hypoglycemia, with infection being a key associated factor. Faster treatment initiation, especially with point-of-care testing, improved outcomes for hypoglycemia management.
Area of Science:
- Emergency Medicine
- Endocrinology
- Clinical Research
Background:
- Hypoglycemia, defined by blood glucose (BG) levels ≤50 mg/dL, requires prompt and effective management in emergency settings.
- Characterizing management patterns and identifying factors contributing to persistent or recurring hypoglycemia is crucial for optimizing patient care.
Purpose of the Study:
- To analyze the management strategies for hypoglycemia in adult emergency department (ED) patients.
- To identify patient characteristics and treatment factors associated with refractory and recurrent hypoglycemia.
Main Methods:
- A retrospective review was conducted on 244 adult ED patients with hypoglycemia (BG ≤50 mg/dL) from January 2011 to July 2015.
- Data included BG measurements, treatment timing, and patient outcomes, analyzed using descriptive statistics and comparative tests.
Main Results:
- 12% of patients with BG ≤50 mg/dL did not receive any treatment or food.
- Treatment was initiated faster with point-of-care testing (11 minutes) compared to serum sample results (25 minutes).
- Refractory or recurrent hypoglycemia occurred in 30.3% of patients, with infection being the only significant associated characteristic.
Conclusions:
- A notable percentage of ED patients with hypoglycemia do not receive timely treatment.
- Infection is linked to refractory or recurrent hypoglycemia, and lack of dextrose-containing IV fluids is associated with recurrence.
- Point-of-care testing expedites hypoglycemia treatment initiation in the ED.
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