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PASylation technology improves recombinant interferon-β1b solubility, stability, and biological activity

Elizaveta A Zvonova1, Alexander V Ershov2, Olga A Ershova2

  • 1International Biotechnology Center (IBC) "Generium", Vladimirskaya street 14, Volginsky village, Petushinsky district, Vladimir Region, 601125, Russia. berkovich@ibcgenerium.ru.

Applied Microbiology and Biotechnology
|November 12, 2016
PubMed
Summary

PASylation enhances recombinant interferon-β1b (IFN-β1b) for treating multiple sclerosis. This modification improves protein stability, solubility, and biological activity, potentially leading to better therapeutic properties.

Keywords:
Biological activityExpressionInterferon-β1bPASylationSolubilityStability

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