A reference system for neuroanatomical localization on functional reconstructed cerebral images

The correlation of anatomical with functional brain images is of critical importance for data analysis. We have designed and tested a reference system method that provides accurate localization of neuroanatomy on functional brain images. The method differs from prior techniques using headholding devices in that it does not require head fixation and is noninvasive. The reference system can be quickly, accurately, and reproducibly applied to the patient's head with respect to the surface anatomy of the head. The reference system is easily adaptable to multiple imaging modalities. The reference system is implemented with the aid of a computer algorithm that reconstructs the anatomic images into a new image matching a selected functional image. Accuracy and reproducibility of placement of the reference system was demonstrated by the application of the system on multiple subjects by two independent observers. The use of this method provides accurate correlation between functional and anatomical brain images.