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Sorbent, device, matrix and application in microextraction by packed sorbent (MEPS): A review
Liu Yang1, Rana Said2, Mohamed Abdel-Rehim3
1State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Summary
Microextraction by packed sorbent (MEPS) is a green sample pretreatment technology that reduces solvent consumption and analysis time. This miniaturized technique is suitable for various analyses and easily integrated with chromatographic systems.
Area of Science:
- Analytical Chemistry
- Green Chemistry
- Sample Preparation
Background:
- Microextraction by packed sorbent (MEPS) is a miniaturized solid-phase extraction technique.
- It is recognized as an environmentally friendly sample pretreatment method.
- MEPS is increasingly adopted for offline and online sample preparation prior to instrumental analysis.
Purpose of the Study:
- To review the optimization of MEPS devices, sorbents, and sample matrices.
- To discuss the applications of MEPS in various analytical fields.
- To explore the progress and future potential of MEPS technology.
Main Methods:
- MEPS utilizes a sorbent bed integrated into a syringe for sample manipulation.
- It supports both manual operation and laboratory robotics.
- The technique is compatible with various chromatographic methods, including LC-MS and GC-MS.
Main Results:
- MEPS offers advantages such as miniaturization, automation, speed, and low solvent/sample consumption.
- It enables seamless online coupling with analytical instruments.
- Successful applications have been demonstrated in pharmaceutical, environmental, and food analysis.
Conclusions:
- MEPS is a simple, fast, and robust sample preparation technique.
- Optimization of sorbent, device, and matrix is crucial for MEPS performance.
- MEPS shows significant potential for further development and widespread application in analytical sciences.
