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Updated: Mar 12, 2026

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
Rare Cause of Infranodal Block
Anwer A Dhala1, Anoop K Singh2
1Aurora Sinai/Aurora St. Luke's Medical Centers, 2801 W Kinnickinnic River Parkway, Suite 777, Milwaukee, WI 53215, USA; Children's Hospital of Wisconsin-Milwaukee Campus, The Medical College of Wisconsin, 8915 W. Connell Ct, Milwaukee, WI 53226, USA.
Abstract:
The patient exhibits multiple features suggestive of Timothy syndrome, which is a multisystem autosomal-dominant condition with findings that include prolonged QT interval, hand and foot abnormalities, dysmorphic facial features, and mental retardation. A 2:1 infranodal atrioventricular block may occasionally be seen in the setting of severely prolonged QT interval. Functional nature of atrioventricular block is demonstrated by resumption of 1:1 conduction with changes in heart rate.
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