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Metabolic Bone Disease in Patients with Malabsorption
Catherine M Phan1, Giuseppe Guglielmi2
1Department of Radiology, Saint-Antoine Hospital, Paris, France.
Seminars in Musculoskeletal Radiology
|November 15, 2016
Summary
Gastrointestinal diseases, including celiac disease and inflammatory bowel disease, can lead to significant bone loss and metabolic changes. This review highlights the complex factors contributing to these bone alterations, often overlooked in patients.
Area of Science:
- Gastroenterology and Bone Metabolism
Background:
- Chronic inflammation and malabsorption in gastrointestinal diseases contribute to bone metabolism alterations.
- Gastrointestinal disease is an underrecognized cause of osteoporosis, osteopenia, and osteomalacia.
Purpose of the Study:
- To review the complex etiology of bone alterations in gastrointestinal diseases.
- To discuss bone changes in celiac disease and inflammatory bowel disease patients with malabsorption.
Main Methods:
- Literature review of studies on bone metabolism in gastrointestinal disease.
- Discussion of multifactorial causes including cytokines and systemic factors.
Main Results:
- Bone alterations in gastrointestinal disease are multifactorial, not solely due to malabsorption.
- Cytokines and local/systemic factors play a complex role in bone formation and resorption.
Conclusions:
- Gastrointestinal diseases significantly impact bone health through complex mechanisms.
- Understanding these mechanisms is crucial for managing bone loss in patients with celiac disease and inflammatory bowel disease.
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