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Related Experiment Videos

Post concussion syndrome: brainstem seizures, a case report.

O J Andy1

  • 1Department of Neurosurgery, University of Mississippi Medical Center 39216-4505.

Clinical EEG (Electroencephalography)
|January 1, 1989
PubMed
Summary

A severe head injury caused chronic headaches and seizures in a young woman. Brain stimulation targeting abnormal electrical activity in the mesothalamus successfully treated these debilitating symptoms.

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Case Study

Background:

  • Chronic intractable headaches and absence attacks following head injury often resist conventional treatment.
  • A 19-year-old female presented with a complex of symptoms post-head trauma, including incapacitating headaches and seizure-like activity.

Observation:

  • During electrode implantation for headache treatment, electrographic recordings identified focal abnormal discharges in the mesothalamus.
  • These abnormal discharges were linked retrospectively to potential head injury-induced brain stem gliosis.

Findings:

  • Electrical stimulation of the mesothalamus successfully attenuated the abnormal discharges.
  • The mesothalamic stimulation resulted in significant alleviation of the patient's chronic headaches and associated symptoms.

Implications:

  • This case suggests mesothalamic electrical malfunctioning, potentially secondary to brainstem gliosis from head trauma, can cause chronic pain syndromes.
  • Brain stimulation may offer a novel therapeutic approach for intractable headache and seizure disorders linked to specific brainstem abnormalities.

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