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Updated: Mar 12, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Obstructive sleep apnea and its controversial effects on cognition.
Maria Devita1, Sonia Montemurro2,3, Sara Ramponi4
1a Department of Human and Social Sciences , University of Bergamo , Bergamo , Italy.
Obstructive sleep apnea syndrome can impact brain function and quality of life. Cognitive difficulties may mimic dementia, but some effects might reverse with treatment.
Area of Science:
- Neurology
- Sleep Medicine
- Cognitive Science
Background:
- Obstructive sleep apnea syndrome (OSAS) is a prevalent sleep disorder.
- OSAS is associated with diverse neurological and cognitive impairments.
- The relationship between OSAS, cognitive decline, and quality of life is a significant concern.
Purpose of the Study:
- To review the current literature on the cognitive consequences of OSAS.
- To explore the debate surrounding OSAS-induced cognitive changes resembling pseudodementia.
- To highlight findings on brain alterations and the potential impact of continuous positive airway pressure (CPAP) treatment.
Main Methods:
- Literature review and synthesis of existing research findings.
- Analysis of studies reporting structural and functional brain changes in OSAS patients.
- Evaluation of evidence regarding executive function deficits and treatment reversibility.
Main Results:
- OSAS is linked to structural and cognitive brain changes, particularly affecting executive functions.
- Evidence suggests that some cognitive impairments may be reversible following CPAP therapy.
- Ongoing debate exists regarding whether OSAS causes pseudodementia.
Conclusions:
- OSAS significantly impacts cognitive functions and quality of life.
- CPAP treatment shows potential for reversing some neurological deficits.
- Further research is needed to fully understand the complex relationship between OSAS and cognitive health.
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