Related Experiment Video
Updated: Mar 12, 2026

09:30
Bacterial Detection & Identification Using Electrochemical Sensors
Published on: April 23, 2013
29.1K
A 155-dB Dynamic Range Current Measurement Front End for Electrochemical Biosensing.
IEEE Transactions on Biomedical Circuits and Systems
|November 16, 2016
Summary
This study presents an ultra-wide dynamic range current measurement system using CMOS technology. The novel dual-mode design offers precise voltage and frequency outputs for sensitive applications.
Area of Science:
- Electrical Engineering
- Instrumentation and Measurement
Background:
- Accurate current measurement is crucial for analyzing complex systems.
- Existing systems often lack the dynamic range or integrated functionality for diverse applications.
Purpose of the Study:
- To develop an integrated current measurement system with an ultra-wide dynamic range.
- To enable concurrent voltage and frequency outputs without external clocking.
Main Methods:
- Fabrication in 180-nm CMOS technology.
- Implementation of a dual-mode design featuring an integrator-differentiator core and an asynchronous current-to-frequency converter.
Main Results:
- Achieved a noise floor of 11.6 fA/sqrt(Hz) and a -3 dB cutoff frequency of 1.4 MHz.
- Demonstrated a 155 dB current measurement range from 204 fA to 11.6 μA.
- Concurrent voltage and frequency outputs were obtained without an external clock.
Conclusions:
- The integrated system offers a wide dynamic range, low noise, and wide bandwidth.
- Ideal for precise measurements in highly nonlinear electrochemical and electrophysiological systems.
- The dual-mode design enhances versatility and simplifies system integration.
Related Concept Videos
Interfacial Electrochemical Methods: Overview
1.0K
Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current...
1.0K
Amperometry: Overview
2.0K
Amperometry is a technique commonly used to measure the concentration of specific analytes in a solution by monitoring the electric current generated during an electrochemical reaction. It involves applying a constant potential between a working electrode and a reference electrode to measure the resulting current, which is proportional to the concentration of the analyte. The Clark oxygen electrode operates based on this principle of amperometry. It consists of a cathode and an anode enclosed...
2.0K
Potentiometry: Membrane Electrodes
2.1K
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
2.1K
Controlled-Current Coulometry: Overview
800
Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
800
Capillary Electrophoresis: Instrumentation
1.5K
Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
1.5K

