Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

68.4K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.4K
Neurulation01:30

Neurulation

46.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
46.9K
Morphogenesis02:19

Morphogenesis

30.7K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.7K
Mesh Analysis01:20

Mesh Analysis

1.6K
Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maximal reproduction number estimation and identification of transmission rate from the first inflection point of new infectious cases waves: COVID-19 outbreak example.

Mathematics and computers in simulation·2022
Same author

SI epidemic model applied to COVID-19 data in mainland China.

Royal Society open science·2021
Same author

Reduction of Prolonged Excessive Pressure in Seated Persons With Paraplegia Using Wireless Lingual Tactile Feedback: A Randomized Controlled Trial.

IEEE journal of translational engineering in health and medicine·2018
Same author

Estimation of life expectancy of patients diagnosed with the most common cancers in the Valparaiso Region, Chile.

Ecancermedicalscience·2017
Same author

Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model.

Physics in medicine and biology·2017
Same author

Wound Healing and Scale Modelling in Zebrafish.

Acta biotheoretica·2016
Same journal

Permanent Scaffolding of Social Expertise.

Acta biotheoretica·2026
Same journal

Who infects whom in an epidemic?

Acta biotheoretica·2026
Same journal

A Discrete Dynamical System Approach for Modeling Wolbachia Infection in Dioecious Populations.

Acta biotheoretica·2026
Same journal

Correction: The Emergence of Turing Instability and Pattern Formation in a Nonlinear Stochastic Spatiotemporal Epidemic Model with Reinfections.

Acta biotheoretica·2026
Same journal

Allele Frequency Spectra as a General Tool for Modeling Genetic Diversity.

Acta biotheoretica·2026
Same journal

Metabolic Scaling from Fibonacci Dynamics.

Acta biotheoretica·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K

Discrete Mesh Approach in Morphogenesis Modelling: the Example of Gastrulation.

J Demongeot1, A Lontos2, E Promayon2

  • 1AGIM, Faculty of Medicine of Grenoble, University J. Fourier, 38700, La Tronche, France. Jacques.Demongeot@agim.eu.

Acta Biotheoretica
|November 18, 2016
PubMed
Summary
This summary is machine-generated.

The shape of the Drosophila melanogaster embryo drives ventral furrow invagination during early embryogenesis. This biomechanical model explains how cell constriction initiates this key developmental process.

Keywords:
Discrete mesh modellingGastrulationMorphogenesisVentral furrow

More Related Videos

Generation of Naïve Blastoderm Explants from Zebrafish Embryos
07:21

Generation of Naïve Blastoderm Explants from Zebrafish Embryos

Published on: July 30, 2021

4.0K
Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.2K

Related Experiment Videos

Last Updated: Mar 12, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K
Generation of Naïve Blastoderm Explants from Zebrafish Embryos
07:21

Generation of Naïve Blastoderm Explants from Zebrafish Embryos

Published on: July 30, 2021

4.0K
Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.2K

Area of Science:

  • Developmental Biology
  • Biophysics
  • Computational Biology

Background:

  • Morphogenesis involves processes generating tissue shapes and cellular organization.
  • Gastrulation, a key embryonic process, involves significant tissue remodeling.
  • Understanding early embryogenesis requires robust modeling of cellular behaviors.

Purpose of the Study:

  • To investigate the link between apical constriction and ventral furrow invagination initiation.
  • To model the early stages of Drosophila melanogaster embryogenesis using a biomechanical approach.
  • To explore the role of embryo geometry in morphogenesis.

Main Methods:

  • Developed a 3D biomechanical model of the Drosophila melanogaster embryo.
  • Utilized the finite element method for simulations.
  • Modeled cells as elastic hexahedron contours with attached neighbors, applying contractile forces.

Main Results:

  • Invagination initiates at the ventral curved extremities and propagates medially.
  • The 'pill-shaped' geometry of the embryo is identified as a key factor in directing invagination.
  • Simulations with spherical geometry (Xenopus laevis) show different invagination patterns.

Conclusions:

  • The specific shape of the Drosophila melanogaster embryo uniquely drives ventral furrow invagination.
  • Apical constriction and embryo geometry are critical for initiating gastrulation.
  • Further research will explore the impact of cell proliferation on furrow closure.