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Updated: Mar 11, 2026

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Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods
Haixia Yang1,2, Lei Xiao1, Nanping Wang3
1Cardiovascular Research Center, Xi'an Jiaotong University, Xi'an, China.
Abstract:
Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.
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