Related Experiment Video
Updated: Mar 11, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Preprocedural High-Sensitivity C-Reactive Protein Predicts Long-Term Outcome of Percutaneous Coronary Intervention
Hideki Wada1, Tomotaka Dohi, Katsumi Miyauchi
1Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine.
Insights
High-sensitivity C-reactive protein (hs-CRP) predicts long-term cardiac events in Japanese patients undergoing percutaneous coronary intervention (PCI). Elevated hs-CRP levels are linked to increased major adverse cardiac events (MACE) and mortality post-PCI.
Area of Science:
- Cardiology
- Biomarkers
- Public Health
Background:
- High-sensitivity C-reactive protein (hs-CRP) is a known predictor of adverse cardiac events in coronary artery disease (CAD) patients post-percutaneous coronary intervention (PCI).
- Limited data exists on the association between hs-CRP and long-term outcomes specifically within the Japanese population after PCI.
Purpose of the Study:
- To investigate the association between preprocedural hs-CRP levels and long-term major adverse cardiac events (MACE) in Japanese patients with CAD undergoing their first PCI.
- To assess the predictive value of hs-CRP for all-cause mortality and other adverse cardiac events in this cohort.
Main Methods:
- A study of 3,039 all-comer patients with CAD who underwent their first PCI between 2000-2011.
- Patients were stratified into tertiles based on preprocedural hs-CRP levels.
- Major adverse cardiac events (MACE), including all-cause death, acute coronary syndrome (ACS), and target vessel revascularization (TVR), were evaluated over a median follow-up of 6.5 years.
Main Results:
- Higher hs-CRP tertiles were associated with increased prevalence of smoking, chronic kidney disease, and ACS, and lower statin use.
- Kaplan-Meier analysis revealed a significant divergence in MACE incidence across hs-CRP tertiles (log-rank P<0.001).
- Multivariable analysis demonstrated that hs-CRP was an independent predictor of MACE (HR 1.10) and all-cause mortality (HR 1.14).
Conclusions:
- Preprocedural hs-CRP measurement is a valuable tool for long-term risk stratification in Japanese patients with established CAD undergoing PCI.
- Elevated hs-CRP levels identify patients at higher risk for adverse cardiac events and mortality after PCI.
Background:
High-sensitivity C-reactive protein (hs-CRP) has been used to predict the risk of adverse cardiac events in patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Less is known, however, about the association between hs-CRP and long-term outcome after PCI in the Japanese population.
Methods And Results:
We studied 3,039 all-comer patients with CAD who underwent their first PCI and had data available for preprocedural hs-CRP at Juntendo University between 2000 and 2011. Patients were assigned to tertiles based on preprocedural hs-CRP concentration. We evaluated the incidence of major adverse cardiac events (MACE) including all-cause death, acute coronary syndrome (ACS), and target vessel revascularization (TVR). Patients with higher hs-CRP had a higher prevalence of current smoking, chronic kidney disease and ACS, and a lower prevalence of statin use. During a median follow-up period of 6.5 years, ongoing divergence in MACE with hs-CRP tertile was noted on Kaplan-Meier curves (hs-CRP <0.08 mg/L, 26.4%; 0.08-0.25 mg/L, 38.2%; >0.25 mg/L, 45.6%; log-rank P<0.001). After adjustment for established cardiovascular risk factors, hs-CRP was associated with higher incidence of MACE (hazard ratio [HR], 1.10; 95% CI: 1.04-1.16, P<0.001) and higher all-cause mortality (HR, 1.14; 95% CI: 1.06-1.22, P<0.001).
Conclusions:
Preprocedural hs-CRP measurement is clinically useful for long-term risk assessment in Japanese patients with established CAD and undergoing PCI.
More Related Videos
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
06:16Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:28Cardiac Catheterization I: Pre-Procedure Overview
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:21Cardiac Catheterization II: Right Heart Catheterization