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Updated: Mar 11, 2026
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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
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Atherosclerotic Renal Artery Stenosis
Robert Schoepe1, Stephen McQuillan1, Debbie Valsan1
1Lankenau Medical Center, 100 Lancaster Avenue, Suite 130, 19096, Wynnewood, PA, USA.
Advances in Experimental Medicine and Biology
|November 23, 2016
Summary
Atherosclerotic Renal Artery Stenosis, a peripheral arterial disease, causes hypertension and kidney damage. Management focuses on controlling lipids, blood pressure, and using anti-platelet agents cautiously.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Vascular Surgery
Background:
- Atherosclerotic Renal Artery Stenosis (ARAS) is a peripheral arterial disease common in older individuals with hyperlipidemia and a history of smoking.
- It can lead to renal artery narrowing, activating the renin-angiotensin-aldosterone system (RAAS), causing resistant hypertension, pulmonary edema, and renal fibrosis.
- An abdominal bruit may indicate ARAS, a slowly progressive condition impacting renal circulation.
Purpose of the Study:
- To review the pathophysiology, diagnosis, and management of Atherosclerotic Renal Artery Stenosis.
- To highlight the challenges in treating ARAS due to its impact on renal hemodynamics and the RAAS system.
Main Methods:
- Review of clinical presentation, diagnostic imaging modalities (ultrasound, CT, MRA, angiography), and therapeutic strategies for ARAS.
- Discussion of recent clinical trial outcomes regarding interventions like stenting and angioplasty.
Main Results:
- Stenting and angioplasty are rarely curative for ARAS, as confirmed by recent large clinical trials.
- Current therapy includes lipid control, blood pressure management, and dual anti-platelet agents.
- ACE inhibitors and ARBs are used cautiously due to the risk of ischemic nephropathy.
Conclusions:
- Optimal blood pressure management and the impact of lifestyle modifications in ARAS require further investigation.
- ARAS management necessitates a comprehensive approach addressing vascular risk factors and potential renal complications.
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