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The Hypertensive Myocardium: From Microscopic Lesions to Clinical Complications and Outcomes

María U Moreno1, Rocío Eiros2, Juan J Gavira3

  • 1Program of Cardiovascular Diseases, Center of Applied Medical Research, University of Navarra, Edificio CIMA, Av. Pío XII, 55, Pamplona 31008, Spain; IdiSNA, Navarra Institute for Health Resarch, Pamplona, Spain.

The Medical Clinics of North America
|November 26, 2016
PubMed

Insights

Hypertension damages the heart, causing structural changes and affecting function. Personalized treatment, guided by biomarkers, is key to managing hypertensive heart disease and reversing left ventricular hypertrophy.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiac Pathophysiology

Background:

  • Chronic hypertension imposes hemodynamic stress on the left ventricle.
  • This leads to myocardial lesions and structural remodeling.
  • These changes adversely affect cardiac function, perfusion, and electrical activity in hypertensive heart disease.

Purpose of the Study:

  • To highlight the need for detecting, reducing, and reversing left ventricular hypertrophy.
  • To emphasize the importance of identifying and repairing microscopic myocardial lesions.
  • To advocate for personalized treatment strategies in hypertensive heart disease.

Main Methods:

  • Focus on the pathophysiology of hypertensive heart disease.
  • Discusses the clinical implications of cardiac remodeling.
  • Proposes biomarker-mediated patient identification for tailored therapies.

Main Results:

  • Hypertension-induced left ventricular remodeling significantly impacts cardiac health.
  • Microscopic myocardial lesions contribute to disease progression.
  • Personalized treatment approaches are crucial for effective management.

Conclusions:

  • Effective management of hypertensive heart disease requires addressing left ventricular hypertrophy and myocardial remodeling.
  • Noninvasive, biomarker-based patient stratification is essential.
  • Personalized treatment can reduce the burden of hypertensive heart disease.

Keywords:
Arterial hypertensionCardiomyocyte apoptosisCardiomyocyte hypertrophyHypertensive heart diseaseLeft ventricular hypertrophyMicrocirculation abnormalitiesMyocardial fibrosis

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