Biomaterial-Based Implantable Devices for Cancer Therapy

Area of Science:

• Biomaterials Science
• Oncology
• Drug Delivery Systems

Background:

• Micro- and nano-particle systems for cancer drug delivery are well-documented.
• Implantable biomaterial devices represent an emerging, versatile platform for cancer treatment.
• These devices offer innovative strategies against tumors, demanding greater scientific attention.

Purpose of the Study:

• To review current local therapies using implanted macroscaled biomaterials for cancer treatment.
• To highlight upcoming research and innovative approaches in biomaterial-based cancer therapy.
• To discuss medical applications, particularly for brain tumors and metastases.

Main Methods:

• Literature review of existing and proposed biomaterial-based implantable devices.
• Analysis of current approaches for local drug administration via biomaterials.
• Exploration of novel strategies including combined therapies and scaffolds.

Main Results:

• Biomaterial devices are effective for local drug delivery, targeting inaccessible tumors like brain metastases.
• Current strategies focus on localized chemotherapy delivery.
• Innovative approaches like scaffolds for gene therapy, immunotherapy, and cell capture are under development.

Conclusions:

• Implantable biomaterials provide advanced, localized cancer treatment options.
• Future trends include multifaceted therapeutic applications beyond drug delivery.
• These platforms hold significant promise for future oncology strategies.