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Infectious Complications in Atopic Dermatitis

Di Sun1, Peck Y Ong2

  • 1Department of Pediatrics, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA.

Immunology and Allergy Clinics of North America
|November 26, 2016
PubMed

Insights

Atopic dermatitis involves skin barrier, immune, and microbiome issues, increasing infection risk. Prevention requires maintaining skin integrity, managing flares, and addressing pathogens.

Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • AD involves a compromised skin barrier, immune dysregulation, and altered skin microbiome.
  • These factors predispose individuals to secondary infections.

Purpose of the Study:

  • To review the pathogenesis of atopic dermatitis.
  • To elucidate the mechanisms of infectious complications in AD patients.
  • To discuss strategies for preventing secondary infections.

Main Methods:

  • Literature review of pathogenesis and infectious mechanisms in atopic dermatitis.
  • Analysis of bacterial, viral, and fungal infections associated with AD.
  • Synthesis of current approaches to infection prevention.

Main Results:

  • Atopic dermatitis pathogenesis involves complex interactions between skin barrier defects, immune responses, and the skin microbiome.
  • Patients with atopic dermatitis are susceptible to infections caused by various pathogens.
  • Acute management of infections is possible, but long-term prevention is crucial.

Conclusions:

  • Secondary infections are a significant concern in atopic dermatitis management.
  • Prevention strategies must address skin barrier function, inflammation control, and pathogen burden.
  • A multipronged approach is essential for preventing and managing infectious complications in AD.
Keywords:
Atopic dermatitisEczema herpeticumInnateKeratinocytesStaphylococcal aureus

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