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Steroid Pulse Therapy for Kawasaki Disease Complicated with Myocarditis

Tomomi Sato1, Junpei Somura, Yoshihiro Maruo

  • 1Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan. Correspondence to: Dr Tomomi Sato, Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan. ttflutedr@yahoo.co.jp.

Indian Pediatrics
|November 28, 2016
PubMed

Insights

Steroid pulse therapy effectively treats Kawasaki disease shock syndrome (KDSS) resistant to intravenous immunoglobulin. This approach offers a promising solution for complex pediatric cases involving myocarditis.

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Critical Care Medicine

Background:

  • Kawasaki disease shock syndrome (KDSS) poses clinical management challenges, particularly when resistant to standard intravenous immunoglobulin (IVIG) treatment.
  • Myocarditis is a serious complication that can arise in KDSS cases, further complicating patient care.

Observation:

  • Three pediatric patients with IVIG-resistant KDSS and associated myocarditis were identified.
  • These cases presented a critical clinical scenario requiring alternative therapeutic strategies.

Findings:

  • All three children with IVIG-resistant KDSS and myocarditis were successfully treated with steroid pulse therapy.
  • This intervention demonstrated significant efficacy in resolving the complex KDSS manifestations.

Implications:

  • Steroid pulse therapy represents a viable and effective treatment option for refractory KDSS, including cases with cardiac involvement.
  • Further research into the application of steroid pulse therapy in KDSS management is warranted to establish optimal protocols and long-term outcomes.
Abstract

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