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Published on: October 5, 2020
TFEB and TFE3: The art of multi-tasking under stress conditions
José A Martina1, Rosa Puertollano1
1a Cell Biology and Physiology Center , National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda , MD , USA.
Abstract:
Cellular adaptation response to a myriad of stressors is key for survival. The lysosomal/autophagy pathway is inextricably connected to the stress response regulation. Two transcription factors, TFEB and TFE3, have recently emerged as master regulators of this degradative pathway. Their function modulating different cellular pathways will be discussed.
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