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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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TH9 cells in skin disorders
Rachael A Clark1, Christoph Schlapbach2
1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Seminars in Immunopathology
|November 30, 2016
Summary
TH9 cells, a T helper cell subset, are increasingly recognized for their role in skin immunity and pathology. Research is exploring how these skin-tropic cells contribute to skin conditions.
Area of Science:
- Immunology
- Dermatology
Background:
- TH9 cells are a recently identified T helper cell subset.
- Evidence suggests TH9 cells play roles in lung, gut, and tumor immunity.
- Their function in skin immunity and immunopathology is not well-defined.
Purpose of the Study:
- To review the current understanding of TH9 cells in skin immunity.
- To explore the involvement of TH9 cells in skin pathology.
- To discuss open questions regarding TH9 cell mechanisms in the skin.
Main Methods:
- Literature review of studies on TH9 cells.
- Analysis of evidence from animal models and human studies.
- Synthesis of current knowledge on TH9 cell tropism and function.
Main Results:
- TH9 cells are predominantly skin-homing and skin-resident in humans.
- These cells may be involved in protection against extracellular pathogens in the skin.
- TH9 cells are implicated as potential mediators of cutaneous pathology.
Conclusions:
- TH9 cells are significant players in skin immunity.
- Further investigation is needed to understand the conditions and mechanisms by which TH9 cells influence skin health and disease.
- Interleukin 9 producing T helper cells present a complex area for future research.
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