Related Experiment Video
Updated: Mar 11, 2026
09:26
Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
10.5K
Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State
G N Manjunatha Reddy1, Aida Huqi2, Dinu Iuga1
1Department of Physics and Department of Chemistry, University of, Warwick, Coventry, CV4 7AL, UK.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 30, 2016
Summary
This study reveals how a lipophilic guanosine derivative forms distinct supramolecular assemblies in solution and solid states. Factors like ions and concentration influence assembly structure, showing reversible interconversion between states.
Area of Science:
- Supramolecular Chemistry
- Nucleoside Chemistry
- Materials Science
Background:
- Lipophilic nucleoside derivatives can form complex supramolecular structures.
- Understanding these assemblies is crucial for developing new functional materials.
- Guanosine derivatives are known to form G-quartets, a key motif in self-assembly.
Purpose of the Study:
- To investigate the self-assembly behavior of a lipophilic guanosine derivative in solution and solid states.
- To elucidate the influence of cations, anions, and concentration on assembly formation.
- To characterize the structural transitions between different supramolecular assemblies.
Main Methods:
- Circular Dichroism (CD) spectroscopy
- Time-course Diffusion-Ordered Nuclear Magnetic Resonance (DOSY-NMR) spectroscopy
- Fast Magic-Angle Spinning (MAS) NMR spectroscopy
- Dissolution NMR experiments
Main Results:
- Distinct supramolecular assemblies, including a metastable species, were observed.
- G-quartet and ribbon-like assemblies formed, influenced by cation, anion, and salt concentration.
- Mixed assemblies were identified in the solid state, even with potassium ions.
- Interconversion between quartet and ribbon assemblies was found to be reversible.
Conclusions:
- The self-assembly of lipophilic guanosine derivatives is sensitive to environmental factors like ions and phase.
- Intermolecular hydrogen bonding dictates the formation of specific assembly types (quartets vs. ribbons).
- The stability of a supramolecular entity can differ significantly between solution and solid states.
Keywords:
2D double-quantum spectroscopyNMR spectroscopyfast magic-angle spinningself-assemblysupramolecular chemistryMore Related Videos
Related Concept Videos
01:24Solid–Solid Solutions
37
The temperature-composition phase diagram of two solids, A and B, which are immiscible in the solid phase but form miscible liquids, shows that when the temperature is low, these two exist as separate, pure solids (A and B). As the temperature increases, they transition into a single-phase liquid solution where A and B coexist. Moving from point a1 to a2 in the phase diagram, the composition changes such that solid B begins to separate from the solution, enriching the remaining liquid with A.
37
01:29The Colloidal State
64
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
64
02:54Molecular and Ionic Solids
20.6K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.6K
01:29Liquid–Solid Solutions
39
The process of a solid dissolving in a liquid to form a solution is governed by the solubility limit, which is the maximum amount of the solid substance, or solute, that can be dissolved in a specific volume of the liquid or solvent. As the solute dissolves, it reaches a point where no more solute can be dissolved at a given temperature - this is known as the saturation point. However, if further solute is added and it manages to dissolve, the solution becomes supersaturated. Supersaturated...
39
02:16Solution Formation
38.7K
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective...
This selective...
38.7K
01:10Recrystallization: Solid–Solution Equilibria
4.2K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
4.2K