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Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
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Transcriptome sequencing of the choroid plexus in schizophrenia.

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The choroid plexus in schizophrenia shows increased immune and inflammation genes, potentially as a protective response to peripheral signals, but this response is insufficient to prevent brain inflammation.

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • The choroid plexus (CP) is vital for brain homeostasis, regulating cerebrospinal fluid (CSF) production and transport.
  • Schizophrenia is associated with immune and inflammatory abnormalities, but the CP's role remains uncharacterized.

Purpose of the Study:

  • To investigate gene expression in the choroid plexus of individuals with schizophrenia.
  • To identify immune and inflammatory pathways involved in the CP in schizophrenia.

Main Methods:

  • mRNA sequencing of choroid plexus tissue from schizophrenia patients and controls.
  • Co-expression network analysis to identify gene modules associated with schizophrenia.
  • Correlation analysis with peripheral and brain inflammatory markers.

Main Results:

  • Upregulation of immune and inflammation-related genes in the CP of individuals with schizophrenia.
  • A significant association between an immune/inflammation co-expression module and schizophrenia.
  • Positive correlations between this module and serum/frontal cortex inflammatory markers (CRP, cortisol, cytokines).
  • Overlap between schizophrenia-associated modules and those from an LPS-treated mouse model.

Conclusions:

  • The CP upregulates immune genes in schizophrenia, likely a response to peripheral inflammation to protect the brain.
  • Despite this response, the CP does not fully prevent neuroinflammation in schizophrenia.