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Lamina cribrosa in glaucoma.

J Crawford Downs1, Christopher A Girkin

  • 1Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

Current Opinion in Ophthalmology
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Glaucoma alters the lamina cribrosa, a key optic nerve structure, causing morphological changes detectable by imaging. These changes, driven by mechanical strain, indicate disease risk and progression.

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Area of Science:

  • Ophthalmology
  • Biomechanics
  • Cellular Biology

Background:

  • The lamina cribrosa is crucial for optic nerve support.
  • Glaucoma is a leading cause of irreversible blindness.
  • Understanding lamina cribrosa changes is vital for glaucoma management.

Purpose of the Study:

  • To review and interpret recent advances in lamina cribrosa research in glaucoma.
  • To contextualize new findings with existing knowledge.

Main Methods:

  • Review of recent scientific literature on lamina cribrosa morphology in glaucoma.
  • Analysis of studies utilizing advanced imaging techniques like optical coherence tomography.

Main Results:

  • The lamina cribrosa is an active structure responding to mechanical strain in glaucoma.
  • Morphological changes include posteriorization, increased cupping, and focal defects.
  • These changes correlate with disk hemorrhages, visual field loss, and are influenced by intraocular pressure and other biomechanical factors.

Conclusions:

  • Lamina cribrosa morphology dynamically changes in health and glaucoma.
  • Identified morphological changes serve as indicators of glaucoma susceptibility, onset, and progression.