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Published on: July 17, 2019
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Receptor tyrosine kinases in carcinogenesis
Xiao-Ying Zhang1, Pei-Ying Zhang2
1Nanjing University of Chinese Medicine, Information Institute, Nanjing, Jiangsu 221009, P.R. China.
Oncology Letters
|December 1, 2016
Summary
Receptor tyrosine kinases (RTKs) regulate vital cell functions. This review focuses on RTK-like orphan receptor 1 (ROR1) and its role in cancer, exploring its potential as a therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Receptor tyrosine kinases (RTKs) are crucial cell surface glycoproteins regulating essential physiological processes like differentiation, survival, and migration.
- Dysregulation, including mutations and overexpression of RTKs, is implicated in numerous human cancers, presenting therapeutic opportunities.
Purpose of the Study:
- To review recent advancements and perspectives on RTK-like orphan receptor 1 (ROR1) in the context of cancer.
- To highlight ROR1 as a potential target for novel anticancer therapies.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of the role of RTKs, specifically ROR1, in cancer development and progression.
Main Results:
- RTKs, including vascular endothelial growth factor receptor, epidermal growth factor receptor, fibroblast growth factor receptor, ROR1, and platelet-derived growth factor receptor, are frequently deregulated in various cancers.
- ROR1 is identified as a significant RTK affected in cancers, offering potential for targeted therapeutic strategies.
Conclusions:
- Targeting deregulated RTKs, particularly ROR1, presents promising avenues for developing new anticancer therapies.
- Monoclonal antibodies and kinase inhibitors are potential therapeutic modalities for targeting RTKs like ROR1 in cancer treatment.
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