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Updated: Mar 11, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Autosomal dominant polycystic kidney disease in children

Kiran Chandra Patro1, R Dilip1, S Ramakrishnan1

  • 1Department of Nephrology, NU Hospitals, Bengaluru, Karnataka, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|December 1, 2016
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) is rare in children, often detected during family screenings. This report details two pediatric cases, highlighting the need for early detection strategies for this genetic kidney disorder.

Area of Science:

  • Nephrology
  • Pediatric Genetics
  • Rare Diseases

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited kidney disorder.
  • While typically diagnosed in adulthood, pediatric ADPKD is less understood.
  • Early-onset ADPKD presentation in children remains unclear.

Observation:

  • Pediatric ADPKD cases are infrequently identified.
  • Diagnosis often occurs through screening of individuals with a significant family history of ADPKD.
  • Symptomatic presentation in children is less common.

Findings:

  • This study presents two pediatric cases of autosomal dominant polycystic kidney disease.
  • The cases contribute to understanding the rare early-onset manifestations of ADPKD.
  • Detailed clinical information on these pediatric patients is provided.

Implications:

  • Highlights the importance of considering ADPKD in pediatric patients, especially with a family history.
  • Suggests potential for earlier diagnostic approaches in at-risk children.
  • Contributes valuable data to the limited knowledge base of childhood ADPKD.

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