Related Experiment Video

Updated: Mar 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.0K

Pediatric Sepsis

Melanie K Prusakowski1, Audrey P Chen2

  • 1Departments of Emergency Medicine and Pediatrics, Virginia Tech Carilion School of Medicine, 1 Riverside Circle, Roanoke, VA 24016, USA.

Emergency Medicine Clinics of North America
|December 3, 2016
PubMed

Insights

Pediatric sepsis differs from adult sepsis, presenting unique challenges in recognition and management due to age-specific factors. This review details clinical presentations and care strategies for sepsis in neonates, infants, and children.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases in children
  • Neonatal and infant health

Background:

  • Pediatric sepsis presents distinct challenges compared to adult sepsis.
  • Recognition is complicated by age-specific vital signs and comorbidities.
  • Mortality is influenced by pediatric-specific health conditions.

Purpose of the Study:

  • To outline the clinical presentation of sepsis in pediatric populations.
  • To detail the management strategies for pediatric sepsis.
  • To highlight specialized care needs for key pediatric groups.

Main Methods:

  • Review of clinical presentations of pediatric sepsis.
  • Analysis of age- and development-specific parameters.
  • Discussion of management protocols for neonates, infants, and children.

Main Results:

  • Pediatric sepsis definitions, presentations, and management vary significantly from adults.
  • Age and developmental stage complicate sepsis recognition in children.
  • Specific comorbidities increase mortality risk in pediatric sepsis.

Conclusions:

  • Effective pediatric sepsis management requires understanding age-specific nuances.
  • Specialized approaches are necessary for neonates, infants, and children with sepsis.
  • Early recognition and tailored interventions are crucial for improving outcomes.

Keywords:
Goal-directed therapyMulti-system organ failureNeonatal sepsisPediatric sepsis

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.9K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
345
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
306
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
411
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
605
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
645
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
573