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Updated: Mar 11, 2026

Homing of Hematopoietic Cells to the Bone Marrow
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Regenerative Endodontics by Cell Homing.

Ling He1, Juan Zhong2, Qimei Gong1

  • 1Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, Columbia University, 630 West 168 Street, New York, NY 10032, USA; Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuan West Road, Guangzhou, Guangdong, 510055, China.

Dental Clinics of North America
|December 4, 2016
PubMed
Summary

Apical revascularization (AR) and platelet-rich plasma show promise for restoring infected immature teeth. Cell homing therapy may offer greater efficacy and consistency compared to traditional regenerative endodontic methods.

Keywords:
Cell homingDental pulpDentinEndodonticsRegenerationRegenerativeTissue engineering

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Area of Science:

  • Dentistry
  • Regenerative Medicine
  • Biomaterials

Background:

  • Apical revascularization (AR) and platelet-rich plasma are investigated for restoring pulp vitality in immature permanent teeth.
  • Cell transplantation and cell homing represent two distinct regenerative approaches.

Purpose of the Study:

  • To update and benchmark cell homing therapy against existing regenerative endodontic techniques.
  • To evaluate the efficacy and procedural sensitivity of cell homing in comparison to AR.

Main Methods:

  • Review and comparison of existing literature on regenerative endodontic therapies.
  • Benchmarking cell homing against cell transplantation and AR based on current evidence.
  • Analysis of procedural and patient variations impacting therapy outcomes.

Main Results:

  • A case report suggested AR increased root length, but this was not supported by quantitative or statistical analysis.
  • Regenerative endodontic therapies necessitate prospective clinical trials for safety and efficacy validation.
  • Cell homing utilizes novel molecules to enhance therapeutic efficacy and may reduce sensitivity to procedural and patient variations.

Conclusions:

  • Prospective clinical trials are crucial for establishing the safety and efficacy of regenerative endodontic therapies.
  • Cell homing therapy presents a potentially more robust and less variable approach to pulp regeneration.