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Genetics of Speciation

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Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.

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Related Experiment Video

Updated: Mar 10, 2026

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster

Published on: December 19, 2011

Gene Regulation and Speciation.

Katya L Mack¹, Michael W Nachman¹

¹Department of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA.

Trends in Genetics : TIG

|December 5, 2016

Summary

This summary is machine-generated.

Regulatory divergence between species can cause hybrid dysfunction through negative genetic interactions. This review explores theoretical and empirical evidence, highlighting gene misregulation

Keywords:

gene expression gene regulation hybrid inviability hybrid sterility speciation

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Area of Science:

Evolutionary biology
Speciation genetics
Gene regulation

Background:

Hybrid dysfunction is a key factor in speciation.
Negative interactions between alleles at multiple genetic loci are a common cause.
Regulatory divergence, affecting gene expression, is a potential driver of these interactions.

Purpose of the Study:

To review how regulatory divergence leads to hybrid dysfunction.
To discuss theoretical support for regulatory divergence in speciation.
To evaluate empirical evidence for regulatory divergence and misregulation in hybrid dysfunction.

Main Methods:

Literature review of theoretical models.
Synthesis of empirical studies on interspecies gene regulation.
Evaluation of evidence linking misregulation to hybrid dysfunction.

Main Results:

Theoretical models support regulatory divergence as a mechanism for hybrid dysfunction.
Empirical evidence suggests regulatory differences between species are common.
Misregulation of genes is implicated as a source of hybrid dysfunction.

Conclusions:

Regulatory divergence is a significant factor in the genetic architecture of speciation.
Further research is needed to resolve outstanding questions in gene regulation and speciation.
Investigating gene misregulation offers promising avenues for understanding reproductive isolation.