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Updated: Aug 12, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Benign familial pemphigus complicated by herpes simplex virus
1Department of Dermatology, Columbia-Presbyterian Medical Center, New York, New York 10032.
Cutis
|September 1, 1989
Summary
Herpes simplex virus can mimic or worsen chronic benign familial pemphigus. Diagnostic tests like Tzanck smear and viral culture confirm the herpes simplex virus, enabling prompt acyclovir treatment.
Area of Science:
- Dermatology
- Virology
Background:
- Chronic benign familial pemphigus, also known as Hailey-Hailey disease, is a rare blistering skin disorder.
- The differential diagnosis of Hailey-Hailey disease can be challenging due to its varied clinical presentations.
Observation:
- Herpes simplex virus (HSV) infections can present with lesions that mimic or complicate existing dermatoses.
- Clinical suspicion of HSV is crucial when pemphigus-like lesions appear or worsen.
Findings:
- Tzanck smear and viral culture are essential diagnostic tools for identifying herpes simplex virus.
- These tests confirm the presence of the pathogen, differentiating it from other blistering conditions.
Implications:
- Early recognition of herpes simplex virus as a precipitating factor or mimic of chronic benign familial pemphigus is vital.
- Prompt diagnosis allows for targeted antiviral therapy with acyclovir, improving patient outcomes and preventing disease exacerbation.
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